INFAT®PLUS, the innovative fat blend developed by Advanced Lipids, is designed to be closer in structure and composition to Chinese human milk fat. It complies with GB standard 30604-2015 for OPO and has all the benefits of high sn-2 palmitate fat – making it the perfect fit for Chinese infant formula.
Human milk provides the optimal nutrition for infants. It offers perfectly balanced nutrition, naturally meeting the needs of growing infants in the first months of life. In human milk, and in most infant formulas, the fat provides about 50% of the energy the newborns require for proper development and growth. More than 98% of this fat is in the form of triglycerides (TG), a common fat molecule comprised of fatty acids attached to a glycerol backbone. The fatty acids are specifically positioned to certain locations called sn-1, sn-2 and sn-3 on the glycerol backbone.
In human milk, palmitic acid (C16:0) the predominant saturated fatty acid, is usually bound, 70-80% of it, to the sn-2 position on the glycerol backbone. This specially structured TG is called sn-2 palmitate. Sn-2 palmitate is highly conserved across populations, found in mothers all over the world, regardless of their nutritional diet, ethnicity or age, suggesting that it may serve an important function.
Oleic acid (18:1n-9) is the major unsaturated fatty acid in human milk and is mostly esterified at the TG sn-1,3 positions (outer). With palmitic and oleic acid being the most abundant fatty acids in human milk, the TGs with the structure Oleic-Palmitic-Oleic (OPO, 18:1n-9-16:0-18:1n-9) are among the major TG species in human milk and represent an estimated ~12% of total TG species.
However, recent data collected from human milk studies in China [1-3] suggests that in China the major TG species found is Oleic-Palmitic-Linoleic (OPL, 18:1n-9-16:0-18:2n-6), and this contrasts with the TG profile in human milk collected in other places, such as Finland , Spain  or Denmark , where the level of OPO is higher than OPL. The basis for this difference has not been fully evaluated yet, but may be related to nutrition.
In most infant formula produced today, the fat component is based on vegetable oil, where most of the palmitic is positioned on sn-1 or sn-3, and not on sn-2. INFAT® the specially structured TG with palmitic bound to the sn-2 position (OPO) was developed for infant formula, so when it is added to infant formula, it elevates the sn-2 palmitate so it is closer to human milk.
INFAT®PLUS, the innovative fat blend developed by Advanced Lipids, is designed to be closer in structure and composition to Chinese human milk fat in all major TG species. INFAT®PLUS complies with GB standard 30604-2015 for OPO and has all the benefits of enriched sn-2 palmitate fat. This makes INFAT®PLUS the best choice for Chinese infant formula.
1) Tu A. et al. A comparative study of triacylglycerol composition in Chinese human milk within different lactation stages and improved infant formula by SFC couple with Q-TOF-MS. Food Chemistry 2017, 221: p. 555–567
2) Kallio H. et al. Triacylglycerol regioisomers in human milk resolved with an algorithmic novel electrospray ionization tandem mass spectrometry method. Food Chemistry 2017, 233: p. 351–360
3) Sun C. et al. Evaluation of triacylglycerol composition in commercial infant formulas on the Chinese market: A comparative study based on fat source and stage. Food Chemistry 2018, 242: p. 29-36
4) Pons SM. et al. Triacylglycerol composition in colostrum, transitional and mature human milk. European Journal of Clinical Nutrition 2000, 54: p. 878-882
5) Zou X. et al. Lipid composition analysis of milk fats from different mammalian species: potential for use human milk substitutes.
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6) Bar-Yoseph, F. et al. SN2-Palmitate Reduces Fatty Acid Excretion in Chinese Formula-fed Infants. Journal of Paediatric Gastroenterology and Nutrition. 2016, 62(2): p. 341-7
7) Litmanovitz I. et al. High Beta-palmitate formula and bone strength in term infants: a randomized, double-blind, controlled trial. Calcified Tissue International 2013, 92(1): p. 35-41
8) Yaron S. et al. Effect of high beta-palmitate content in infant formula on the intestinal microbiota of term infants. Journal of Paediatric Gastroenterology and Nutrition 2013, 56(4): p. 376-81
9) Litmanovitz, I. et al. Reduced crying in term infants fed high beta-palmitate formula: a double-blind randomized clinical trial. BMC Pediatrics 2014, 14: p. 152
10) Bar-Yoseph, F. et al. SN2-Palmitate Improves Crying and Sleep in Infants Fed Formula with Prebiotics: A Double-Blind Randomized Clinical Trial. Clinics in Mother and Child Health 2017, 14(2)
11) Lu, P., et al., High beta-palmitate fat controls the intestinal inflammatory response and limits intestinal damage in mucin Muc2 deficient mice. PLoS One 2013, 8(6): p. e65878
12) Bar-Maisels, M. et al. Beta Palmitate Improves Bone Length and Quality during Catch-Up Growth in Young Rats. Nutrients 2017, 9(7)
The clinical support described here is based on studies conducted with INFAT only. Data specific to INFAT MF, INFAT PRO or INFAT PLUS is not available at this time.