INFAT® was tested in a pre-clinical study and was
shown to have a protective role in intestinal inflammation
Our bodies are constantly exposed to microorganisms present in the environment, which may be harmful. One of the places in our body where such interaction occurs is in the gastrointestinal tract. The human gastrointestinal tract is equipped with physical and biological barriers whose function is to isolate the internal part from the external environment and to regulate the immune system. The intestine has a special mucus layer which functions as a physical barrier, protecting it from microbes. Inflammation of the mucus layer may compromise the gut barrier integrity. Pre-mature infants are prone to develop intestinal inflammation, and we tested if a diet enriched with high sn2 palmitate can protect the intestine from inflammatory damage and support intestinal health.
The study was performed on special mice that are lacking mucin2 (Muc2 deficient mice), a principal component of the intestinal mucus layer. The deficiency of mucins in the Muc2-/- mice affects the protective capacities of the mucus layer, and as a consequence, bacteria are in direct contact with the intestinal epithelial cells. This in its turn leads to the development of spontaneous colitis in Muc2 deficient mice. In this study mice fed diet with INFAT® demonstrated a lower extent of intestinal inflammatory damage compared with mice fed the control diet.
A preclinical study revealed the potential protective role of INFAT® in a spontaneous colitis mice model, showing that a low sn2 palmitate diet increased intestinal damage while a high sn2 palmitate diet limited the damage, though both diets contained the same palmitic acid content. This data suggests that low sn2 palmitate levels may impact intestinal inflammation although further work is needed to correlate these findings with a potential impact on infant health.